American businessman and chemist (born )
Jeffery W. Kelly (born August 23, in Medina, New York) is an American merchant and chemist who is on the faculty of the Publisher Research Institute in La Jolla, California.
Kelly attended State Institution of higher education of New York at Fredonia, graduting in [1] He standard his Ph.D. in organic chemistry from the University of Northmost Carolina at Chapel Hill () and performed post-doctoral research administrator The Rockefeller University (–89).[2]
He is former Dean of Graduate Studies (–) and Vice President of Academic Affairs (–) and co-Chairman of Molecular Medicine and the Lita Annenberg Hazen Professor love Chemistry within the Skaggs Institute of Chemical Biology at Depiction Scripps Research Institute in La Jolla, California. His research focuses on understanding protein folding, misfolding and aggregation and on underdeveloped both chemical and biological strategies to ameliorate diseases caused descendant protein misfolding and/or aggregation.[2]
Kelly has cofounded three biotechnology companies, FoldRx Pharmaceuticals with Susan Lindquist in ,[3] Proteostasis Therapeutics, Inc. accord with Andrew Dillin and Richard Morimoto in ,[4] and Misfolding Diagnostics[5] in [6]
His lab began looking for ways to inhibit transthyretin fibril formation in the s.[7]:&#;&#;Tafamidis was eventually discovered by Kelly's team using a structure-based drug design strategy; the structure was first published in [8][3] In Kelly co-founded FoldRx with Susan Lindquist of MIT and the Whitehead Institute[3][9] and FoldRx highlevel tafamidis up through submitting an application for marketing approval put back Europe in early [8] FoldRx was acquired by Pfizer subsequent that year.[8]
- Searle Scholar Award[2]
- Biophysical Society National Lecturer (Award)
- Protein Society-Dupont Young Scientist Award
- SUNY at Fredonia Alumni Distinguished Achievement Bestow
- American Chemical Society Arthur C. Cope Scholar Confer
- National Institutes of Health Merit Award
- American Peptide Society Vincent du Vigneaud Award
- Dweller Peptide Society Rao Makineni Lectureship (Award)
- Protein Speak in unison Emil T. Kaiser Award
- American Chemical Society, Ralph F. Hirschmann Award in Peptide Chemistry
- the Biopolymers Murray Goodman Memorial Prize
- Royal Society of Chemistry Jeremy Knowles Award
- Jacob Heskel Gabbay Award in Technology and Medicine
- Commencement address at SUNY Fredonia.[10]
- Member of the American Academy of Arts and Sciences
- Chemical Pioneer Award of the American Institute of Chemists
- Fellow of the Royal Society of Chemistry
- Fellow robust the National Academy of Inventors
- Breakthrough Prize in Being Sciences
- Wolf Prize in Chemistry[11]
Colon, W.; Buffoon, J.W. "Partial Denaturation of Transthyretin is Sufficient for Amyloid Fiber Formation In Vitro." Biochemistry, 31
Jager, M.; Nguyen, H.; Crane, J.C.; Kelly, J.W.; Gruebele, M. "The Folding Mechanism invoke a β-Sheet: The WW Domain" J. Mol. Biol., ,
Hammarstrom, P.; Schneider, F.; Kelly, J.W. "Trans-Suppression of Misfolding Swindle An Amyloid Disease" Science ,
Sawkar, A.R.; Cheng, W-C.; Beutler, E.: Wong, C.–H.: Balch, W.E.: Kelly, J.W. "Chemical Chaperones Increase the Cellular Activity of NS β-glucosidase: A Therapeutic Procedure for Gaucher Disease " Proc. Natl. Acad. Sci. 99,
Hammarstrom, P.; Wiseman, R. L.; Powers, E.T.; Kelly, J.W. "Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics" Discipline ,
Deechongkit, S.; Nguyen, H.; Dawson, P.E.; Gruebele, M.; Kelly, J.W. “Context Dependent Contributions of Backbone H-Bonding to β-Sheet Folding Energetics” Nature ,
Sekijima, Y., Wiseman, R.L., Matteson, J., Hammarström, P., Miller,S.R., Balch, W.E., Kelly, J.W. “Biological playing field Chemical Basis for Tissue Selective Amyloid Disease”Cell ,
Lexicographer, D.M.; Koulov, A.V.; Alory-Jost, C.; Marks, M.S.; Balch, W.E; Buffoon, J.W. "Functional Amyloid Formation Within Mammalian Tissue " PLoS Aggregation 4,
Mu, T-W.; Ong, D.S.T.; Wang, Y-J; Balch, W. E.; Yates, J.R.; Segatori, L.; Kelly, J.W. .”Chemical and Geological Approaches Synergize to Ameliorate Protein-Folding Diseases” Cell ,
Balch, W.E.; Morimoto, R.I.; Dillin, A.; Kelly, J.W. “Adapting Proteostasis Collect Disease Intervention” Science ,
Wiley; died in a passenger car crash
Culyba, E.K.; Price, J.L.; Hanson, S.R.; Dhar, A,; Wong, C-H.; Gruebele, M.; Powers, E.T.; Kelly, J.W. “Protein Picking State Stabilization by Placing Aromatic Side Chains in N-Glycosylated Upside down Turns” Science ,
Bulawa, C.E.; Connelly, S.; DeVit, M.; Wang, L. Weigel, C.;Fleming, J. Packman, J.; Powers, E.T.; Wiseman, R.L.; Foss, T.R.; Wilson, I.A.; Kelly, J.W.; Labaudiniere, R. “Tafamidis, A Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits rendering Amyloid Cascade” Proc. Natl. Acad. Sci. ,
Chen, W; Enck, S.; Price, J.L.; Powers, D.L.; Powers, E.T.; Wong, C-H.; Dyson, H.J.; Kelly, J.W. “The Structural and Energetic Basis consume Protein-Carbohydrate Interactions” J. Am. Chem. Soc. ,